LoMenzo joined MEGADETH in 2006 and appeared on two of the group’s studio albums, 2007’s “United Abominations” and 2009’s “Endgame”. He was fired from the band in 2010 and replaced with returning original MEGADETH bassist David Ellefson.

In addition to MEGADETH, LoMenzo has played with Ozzy Osbourne, Zakk Wylde and WHITE LION. For the past nine years, LoMenzo has been performing with iconic rocker John Fogerty.

During an appearance on a March 2022 episode of SiriusXM‘s “Trunk Nation With Eddie Trunk”, Mustaine discussed MEGADETH‘s reunion with LoMenzo, saying: “I’m thrilled. I think he’s a really awesome person to have in MEGADETH. He was when we tried it the first time. And for whatever reason that things happen, things happened and we took a little sabbatical from playing together. And when things happened as they did, it was obvious to me that I needed to get a super kickass bass player to come in and cut all the tracks and learn ’em in relatively no time, because we were in the studio already, so I needed to get somebody that could really do all that stuff. And I hadn’t made up my mind on James yet. So I ended up asking a super, super legendary bass player in the metal community, Steve DiGiorgio. I asked him if he would come in and guest on the upcoming MEGADETH record and help me to finish the record and cut bass parts. So he came out, and that was really wonderful to hear his interpretation of my songs and the stuff that Kiko and Dirk and I, the stuff that we’re starting to write together; we’re starting to really develop our chemistry.”

MEGADETH‘s new album, “The Sick, The Dying, And The Dead”, is tentatively due on July 8. The follow-up to “Dystopia” features a cover of DEAD KENNEDYS‘ “Police Truck” and Sammy Hagar‘s “This Planet’s On Fire”, the latter of which includes vocals from Hagar himself.

Ellefson laid down his bass tracks on MEGADETH‘s sixteenth LP in May 2020 at a studio in Nashville, Tennessee. A short time later, he raved about his performance on the record, telling the 96.7 KCAL-FM radio program “Wired In The Empire” that his musical chemistry with Verbeuren was comparable to the interplay between Geddy Lee and Neil Peart on classic RUSH albums. “I feel like on the new MEGADETH record, me and Dirk have those same moments,” he said. “It’s MEGADETH — it’s not RUSH, obviously — but in the field of what we do, there were these moments that I was just going, ‘Oh, my God.’ This is me as a kid going, ‘This is my Geddy/Neil moment right here.'”

In June 2021, Mustaine announced during an episode of his Gimme Radio program “The Dave Mustaine Show” that Ellefson‘s bass tracks would not be used on the new MEGADETH LP.